June 1, 1999RNAOpen Access

The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon

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Population

Chimeric picornavirus IRESes

Design

Preclinical

Authors

TOThéophile OhlmannUniversité Claude Bernard Lyon 1 RJRichard J. JacksonUniversity of Liverpool

Discussion

Member takes

Implication

IRES body dictates AUG selection in viral RNAs; extends translation models but leaves open mammalian relevance.

Structured PICO

Population

Chimeric picornavirus IRESes (encephalomyocarditis virus [EMCV], foot-and-mouth-disease virus [FMDV], and poliovirus [PV])

Intervention

Construction of chimeras with a crossover at the conserved UUUC motif (replacing the body of FMDV or PV IRESes with that of EMCV, or replacing the body of EMCV IRES with that of PV)

Outcome

Absolute and relative frequency of translation initiation at specific AUG sites

The behavior of the ribosome during translation initiation is highly dependent on the nature of the upstream IRES, not just the context of the AUG codon.

Cite This Study

Ohlmann et al. (1999) studied this question.

synapsesocial.com/papers/6a7c113ba540d02696c2bf9a https://doi.org/10.1017/s1355838299982158

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The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider