Key result
Ribosomes first bind at the AUG-576 site of the human rhinovirus 2 internal ribosome entry site, but instead of initiating there, most are transferred to AUG-611 by linear scanning.
The study elucidates the mechanism of translation initiation site selection in human rhinovirus 2, showing that ribosomes bind at AUG-576 and transfer to AUG-611 primarily via linear scanning.
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Refines picornavirus IRES models; extends mechanistic understanding but leaves open human relevance and therapeutic implications.
Kaminski et al. (2010) studied this question. HRV-2 IRES domain VI mutations vs. Wild-type HRV-2 IRES was evaluated on Translation initiation site usage (relative initiation frequency at AUG codons). Ribosomes first bind at the AUG-576 site of the human rhinovirus 2 internal ribosome entry site, but instead of initiating there, most are transferred to AUG-611 by linear scanning.
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