January 15, 1997Nucleic Acids ResearchOpen Access

A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs

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Population

5'-non-translated regions of human immunoglobulin heavy chain binding protein, Antennapedia of Drosophila…

Design

Preclinical

Authors

SLSon C. LeDuke University

Discussion

Member takes

Implication

Conserved Y-type motif supports IRES hypothesis in cellular mRNAs; leaves open functional validation in mammalian systems.

Structured PICO

Population

5'-non-translated regions (5'NTR) of human immunoglobulin heavy chain binding protein (BiP), Antennapedia (Antp) of Drosophila and human fibroblast growth factor 2 (FGF-2) mRNAs

Intervention

Statistical analyses of RNA folding and structural analyses

Outcome

Identification of conserved RNA structural motifs

A common Y-type stem-loop RNA structural motif is conserved in diverse BiP and FGF-2 mRNAs, suggesting a general function in the internal ribosome binding mechanism of cellular mRNAs.

Cite This Study

Son C. Le (1997) studied this question.

synapsesocial.com/papers/6a72dc99da24de05641ae596 https://doi.org/10.1093/nar/25.2.362

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A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider