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July 15, 1997Nucleic Acids ResearchOpen Access

Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions

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Population

Cultured mammalian cells and thiouridine-labeled human immunoglobulin heavy chain binding protein…

Design

Preclinical

Authors

QYQin YangAnhui Medical University

Discussion

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Implication

No immediate clinical implications from this animal study; leaves open whether p60/p95 mediate BiP IRES activity in human cardiovascular ER stress.

Structured PICO

P
Population
Cultured mammalian cells and thiouridine-labeled human immunoglobulin heavy chain binding protein (BiP) IRES-containing RNA
I
Intervention
Crosslinking of RNA to cellular proteins
O
Outcome
Location of the internal ribosome entry site (IRES) and identification of specific RNA-protein interactions

The study identifies specific cellular proteins (p60 and p95) that bind to the BiP mRNA IRES, suggesting a role in internal initiation of translation for both cellular and viral IRES elements.

Cite This Study

Qin Yang (1997) studied this question.

synapsesocial.com/papers/6a70f89cfebe604dd709b885https://doi.org/10.1093/nar/25.14.2800
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.1989 · 139 citations
  2. 2Conserved tertiary structural elements in the 5’ nontranslated region of cardiovirus, aphthovirus and hepatitis A virus RNAs1993 · 57 citations