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August 19, 2026Advances in Clinical Medical ResearchOpen Access

Molecular Epidemiology of Dengue Virus Serotypes and Their Association With Disease Severity

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Authors

MAMohammad Zulfiqar AliKJKailash Jatav

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Overview

Observational study reveals DENV-2 predominance and severe outcomes in suspected dengue patients, highlighting the diagnostic utility of molecular surveillance.

Key Points

  • To investigate the molecular epidemiology of circulating dengue virus serotypes (DENV-1 through DENV-4) and evaluate their clinical associations with disease severity.
  • Conducted a cross-sectional observational study of 290 clinically suspected dengue patients at a tertiary care hospital in Indore, Madhya Pradesh (January 2023 to January 2026).
  • Screened serum samples using a rapid antigen/antibody test and performed viral RNA detection and serotyping via real-time RT-PCR.
  • Assessed clinical and hematological parameters and evaluated risk factors for severe dengue using multivariate logistic regression.
  • Confirmed dengue infection by real-time RT-PCR in 23.1% (67/290) of cases, with DENV-2 being predominant (46.3%), followed by DENV-3 (26.9%), DENV-1 (20.9%), DENV-4 (3.0%), and mixed-serotype infections (3.0%).
  • DENV-2 infection demonstrated a significant association with severe dengue (OR 2.91, 95% CI: 1.28–6.62; p=0.009).
  • Identified platelet count <50,000/µL as the strongest independent predictor of severe disease (OR 4.72, 95% CI: 2.01–11.08; p<0.001), along with bleeding manifestations (OR 3.18; p=0.011) and abdominal pain (OR 2.37; p=0.039).

Cite This Study

Ali et al. (2026) studied this question.

synapsesocial.com/papers/6a85636403308d306e2d675chttps://doi.org/10.5281/zenodo.21966415
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dengue Virus Serotype Distribution and Disease Severity: Evidence from Molecular Surveillance in Karnataka, India2026
  2. 2Circulating dengue virus serotypes in central India: a molecular surveillance study2026
  3. 3Pan- India molecular surveillance of dengue serotypes, 2023-20252026
  4. 4Dengue serotypes and their severity correlation: A hospital-based observational study2026
  5. 5P-1807. A Study on Clinical, Laboratory Parameters and Outcome Among Patients Infected with Different Dengue Serotypes in a Tertiary Care Hospital2026