What question did this study set out to answer?

Synthesize a series of N-substituted pyruvamide 4-allylthiosemicarbazones and their copper(II) complexes to characterize their structure and evaluate their anticancer, antiradical, and antimicrobial activities.

August 19, 2026MoleculesOpen Access

Synthesis and Biological Evaluation of a Series of N-Substituted Pyruvamide 4-Allylthiosemicarbazones and Their Copper(II) Complexes: Antibacterial, Antiradical, and Antiproliferative Activities

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Authors

IGIanina GraurMoldova State University DIDorin IstratiNicolae Testemițanu State University of Medicine and Pharmacy VGVasilii GraurMoldova State University

Discussion

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Implication

In vitro study reveals potent antiproliferative and antiradical activities of novel copper(II) thiosemicarbazones in cancer cells, indicating potential for new therapeutics.

Key Points

Synthesize a series of N-substituted pyruvamide 4-allylthiosemicarbazones and their copper(II) complexes to characterize their structure and evaluate their anticancer, antiradical, and antimicrobial activities.
Synthesized ligands HL1–6 and copper(II) complexes 1–6, confirming structures via elemental analysis, FTIR, 1H and 13C NMR spectroscopy, and single-crystal X-ray diffraction for HL2, HL4, and HL6.
Tested biological properties using antiproliferative assays against three human cancer cell lines (including THP-1 leukemia) and normal hTERT-RPE1 cells, along with antiradical and antimicrobial assays.
Copper(II) complexes demonstrated higher anticancer activity than free ligands, with complexes 1 and 3 outperforming reference doxorubicin in select cases and yielding selectivity indices > 10 for THP-1 leukemia over normal hTERT-RPE1 cells.
Uncomplexed thiosemicarbazones HL1–6 exhibited high antiradical activity that exceeded the potency of both the copper(II) complexes and the standard antioxidant Trolox.
Copper(II) coordination compounds showed moderate antibacterial and antifungal properties that did not exceed standard reference drugs.

Cite This Study

Graur et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6937 https://doi.org/10.3390/molecules31162857

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August 19, 2026MoleculesOpen Access

Synthesis and Biological Evaluation of a Series of N-Substituted Pyruvamide 4-Allylthiosemicarbazones and Their Copper(II) Complexes: Antibacterial, Antiradical, and Antiproliferative Activities

View Full Paper

Ask AI

Bookmark

Authors

IGIanina GraurMoldova State University DIDorin IstratiNicolae Testemițanu State University of Medicine and Pharmacy VGVasilii GraurMoldova State University

Discussion

Member takes

Implication

In vitro study reveals potent antiproliferative and antiradical activities of novel copper(II) thiosemicarbazones in cancer cells, indicating potential for new therapeutics.

Key Points

Synthesize a series of N-substituted pyruvamide 4-allylthiosemicarbazones and their copper(II) complexes to characterize their structure and evaluate their anticancer, antiradical, and antimicrobial activities.
Synthesized ligands HL1–6 and copper(II) complexes 1–6, confirming structures via elemental analysis, FTIR, 1H and 13C NMR spectroscopy, and single-crystal X-ray diffraction for HL2, HL4, and HL6.
Tested biological properties using antiproliferative assays against three human cancer cell lines (including THP-1 leukemia) and normal hTERT-RPE1 cells, along with antiradical and antimicrobial assays.
Copper(II) complexes demonstrated higher anticancer activity than free ligands, with complexes 1 and 3 outperforming reference doxorubicin in select cases and yielding selectivity indices > 10 for THP-1 leukemia over normal hTERT-RPE1 cells.
Uncomplexed thiosemicarbazones HL1–6 exhibited high antiradical activity that exceeded the potency of both the copper(II) complexes and the standard antioxidant Trolox.
Copper(II) coordination compounds showed moderate antibacterial and antifungal properties that did not exceed standard reference drugs.

Cite This Study

Graur et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6937 https://doi.org/10.3390/molecules31162857

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