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August 19, 2026Journal of Drug Delivery and TherapeuticsOpen Access

Polyherbal Mucoadhesive Gel: A Promising Approach for the Treatment of Oral Candidiasis

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Authors

RSRachana Amit SalunkheGovernment Medical CollegeASAnushka A ShahGovernment Medical College

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Implication

Review highlights polyherbal mucoadhesive gels for oral candidiasis, suggesting botanical formulations enhance local drug delivery and overcome antifungal resistance.

Key Points

  • To review the therapeutic potential, mechanism of action, and formulation benefits of polyherbal mucoadhesive gels as an alternative treatment for oral candidiasis.
  • Literature review analyzing the pathophysiology of oral candidiasis and the shortcomings of conventional antifungals such as nystatin, clotrimazole, and fluconazole.
  • Evaluation of mucoadhesive polymers, specifically Hydroxypropyl Methylcellulose (HPMC) and Carbopol, alongside botanical essential oils for localized oral drug delivery.
  • Mucoadhesive polymers prolong retention time at oral infection sites, facilitate controlled botanical release, and physically protect irritated mucosal tissues.
  • Essential oils including lemongrass, oregano, clove, and tea tree demonstrate broad anti-Candida albicans activity via membrane disruption, oxidative stress, and biofilm prevention.

Cite This Study

Salunkhe et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d6a36https://doi.org/10.22270/jddt.v16i8.7889
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antifungal Activity, Cytocompatibility, and Wound Healing Potential of Novel Mucoadhesive Formulations for Oral Drug Delivery2025 · 2 citations
  2. 2Mucoadhesive Gel Based on Cinnamomum cassia Essential Oil and Punica granatum Extract for Oral Candidiasis: A Pilot Study of Plant Synergism2026
  3. 3Association of mucoadhesive polymeric matrices and liposomes for local delivery of miconazole: A new approach for the treatment of oral candidiasis2024 · 7 citations
  4. 4Formulation and Development of a Herbal Antifungal Gel Containing Origanum vulgare and Syzygium aromaticum Essential Oils Against Oral Candida albicans2024 · 4 citations
  5. 5Thermoresponsive carbohydrate polymer mucoadhesive gel for synergistic delivery of acarbose and fluconazole against Candida biofilms2026