What type of study is this?

This is a Quantitative Study study.

September 23, 2025Journal of Biomedical Materials Research Part AOpen Access

Antifungal Activity, Cytocompatibility, and Wound Healing Potential of Novel Mucoadhesive Formulations for Oral Drug Delivery

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Authors

CSCarolina Yoshi Campos SugioUniversidade Sagrado Coração VMVíctor MartínUniversidade do Porto LGLídia GonçalvesUniversity of Lisbon

Discussion

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Implication

Novel mucoadhesive formulations demonstrated improved antifungal and cytocompatibility effects against Candida albicans, indicating potential for better oral drug delivery.

Key Points

Mucoadhesive gels with βCD-complexed nystatin or chlorhexidine significantly improved antifungal activity compared to standard treatments.
Cytocompatibility tests showed that drug-complexed gels maintained fibroblast viability while lowering LDH release and similar apoptosis rates.
The study highlighted enhanced wound healing potential, with modified gels achieving complete wound closure and significant anti-inflammatory effects.
Mucoadhesiveness of the developed formulations was superior to standard treatment, promising a better therapeutic approach for oral candidiasis.

Cite This Study

Sugio et al. (2025) studied this question.

synapsesocial.com/papers/68d4724731b076d99fa6a91e https://doi.org/10.1002/jbm.a.37990

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Implication

Novel mucoadhesive formulations demonstrated improved antifungal and cytocompatibility effects against Candida albicans, indicating potential for better oral drug delivery.

Antifungal Activity, Cytocompatibility, and Wound Healing Potential of Novel Mucoadhesive Formulations for Oral Drug Delivery

Discussion

Member takes

Implication

Key Points

Cite This Study

Antifungal Activity, Cytocompatibility, and Wound Healing Potential of Novel Mucoadhesive Formulations for Oral Drug Delivery

Discussion

Member takes

Implication

Key Points

Cite This Study

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