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February 1, 1989Journal of General Virology

T Cell-dependent Induction of Antibody against Foot-and-Mouth Disease Virus in a Mouse Model

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Population

Nude and normal BALB/c mice, and C57BL/6 mice spleen cell cultures

Comparison

Intravenous inoculation of purified, infectious… vs Nude vs normal mice; T cell depleted vs…

Design

Preclinical

Authors

TCT. CollenMedical University of South Carolina LPL. PullenUniversity of Duisburg-Essen TDT.R. DoelThe Pirbright Institute

Discussion

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Implication

T cell dependence of anti-FMDV IgG in mice leaves open translation to livestock vaccines; hypothesis-generating for lymphokine modulation pending target-species studies.

Structured PICO

P

Population

Nude and normal BALB/c mice, and C57BL/6 mice spleen cell cultures

I

Intervention

Intravenous inoculation of purified, infectious foot-and-mouth disease virus (FMDV) type A24, strain Cruzeiro

C

Comparator

Nude vs normal mice; T cell depleted vs reconstituted spleen cell cultures

O

Outcome

Frequency of antigen-specific antibody-secreting cells (ASC), Thy 1+ T cells, and induction of IgGsurrogate

This preclinical study demonstrates that the induction of IgG against FMDV is T cell-dependent and regulated by lymphokines.

Cite This Study

Collen et al. (1989) studied this question.

synapsesocial.com/papers/6a8564fb43622fd4ea6721be https://doi.org/10.1099/0022-1317-70-2-395

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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

1Induction of antibody to foot-and-mouth disease virus in presensitized mouse spleen cell cultures1984 · 18 citations
2Immunity to foot-and-mouth disease virus in guinea pigs: clinical and immune responses1979 · 41 citations
3A blastogenic test for foot-and-mouth disease1979 · 11 citations