Duration of the foot-and-mouth disease virus antibody response in mice is closely related to the presence of antigen-specific presenting cells.

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Population

Mice (FMDV-infected or immunized with inactivated virus)

Comparison

Transfer of spleen cells from FMDV-infected… vs Untreated animals; normal or irradiated…

Design

Preclinical

Follow-up

>210 days

Authors

Discussion

Supports persistent APCs in sustaining anti-FMDV immunity in mice; leaves open relevance to natural hosts or vaccines.

Population

Mice (FMDV-infected or immunized with inactivated virus)

Intervention

Transfer of spleen cells from FMDV-infected mice; immunization with inactivated virus

Comparator

Untreated animals; normal or irradiated recipient mice

Outcome

Anti-FMDV antibody response and presence of antigen-presenting cells (APC)surrogate

Persistent FMDV antigen-presenting cells are responsible for the maintenance of an anti-virus immune response in mice.

Wigdorovitz et al. (1997) studied this question.

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