Key result
Vaccination with a homologous adenovirus-vectored vaccine did not prevent foot-and-mouth disease virus persistence, which occurred in 54.5% of vaccinated and 61.5% of non-vaccinated cattle.
Population
47 Holstein steers (6 to 8 months, ~200 kg)
Comparison
Recombinant FMD serotype A vaccine administered… vs Non-vaccinated steers challenged with FMDV A24
Design
Preclinical
Follow-up
up to 35 days
Authors
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Hypothesis-generating for host factors in FMDV persistence; leaves open whether T-cell profiles guide cattle vaccination.
Absolute Event Rate: 54.5% vs 61.5%
Vaccination against FMDV altered the systemic immune response but did not significantly change the incidence of viral persistence in cattle.
Eschbaumer et al. (2016) studied Foot-and-mouth disease virus (FMDV) infection (n=47). Recombinant FMD serotype A vaccine vs. Non-vaccinated was evaluated on Incidence of FMDV persistence (carrier status). Vaccination with a homologous adenovirus-vectored vaccine did not prevent foot-and-mouth disease virus persistence, which occurred in 54.5% of vaccinated and 61.5% of non-vaccinated cattle.
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