Why the study?
It was unknown whether selective renal afferent denervation plays a beneficial role in attenuating oxidative stress and sympathetic activity in hypertension.
Does selective renal afferent denervation reduce hypertension, oxidative stress, and vascular remodeling in spontaneously hypertensive rats?
Population
Nine-week-old normotensive Wistar-Kyoto rats and spontaneously hypertensive rats
Comparison
Selective renal afferent denervation with capsaicin vs vehicle control
Design
Animal experimental study
Authors
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Hypothesis-generating for selective renal afferent denervation in hypertension; prospective human trials needed before clinical adoption.
Does selective renal afferent denervation reduce hypertension, oxidative stress, and vascular remodeling in spontaneously hypertensive rats?
Selective removal of renal afferents attenuates sympathetic activity, oxidative stress, vascular remodeling, and hypertension in a rat model.
Wu et al. (2022) studied this question.
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