Key result
Renal denervation in adult spontaneously hypertensive rats significantly decreased arterial pressure compared to sham (182 vs 207 mmHg, P<0.05) and reduced total peripheral resistance.
Why the study?
Does bilateral renal denervation improve systemic and regional haemodynamics in spontaneously hypertensive rats?
Population
Adult (six-month-old) male spontaneously hypertensive rats (SHR)
Comparison
Bilateral renal denervation performed five to… vs Sham procedure
Design
Preclinical
Follow-up
5 to 8 days
Authors
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Renal denervation hemodynamics in hypertensive rat models merit further exploration; leaves open translation to human hypertension.
Does bilateral renal denervation improve systemic and regional haemodynamics in spontaneously hypertensive rats?
Effect estimate: -12%
Absolute Event Rate: 182% vs 207%
p-value: p=<0.05
Bilateral renal denervation in spontaneously hypertensive rats lowers arterial pressure primarily through a reduction in total peripheral resistance, with a major contribution from decreased renal vascular resistance.
Lee et al. (1983) studied Hypertension. Renal denervation vs. Sham was evaluated on Arterial pressure (mmHg) (-12%, p=<0.05). Renal denervation in adult spontaneously hypertensive rats significantly decreased arterial pressure compared to sham (182 vs 207 mmHg, P<0.05) and reduced total peripheral resistance.
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