Why the study?
Does renal denervation improve blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats?
Population
48 male spontaneously hypertensive rats
Comparison
Renal denervation achieved by cutting off renal… vs Sham-operation and control groups
Design
Preclinical, randomized to three groups
Follow-up
10 weeks after RD, then 120 min observation after…
Authors
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Renal denervation may aid early BP recovery after hemorrhagic shock in hypertensive models; leaves open human translation and mechanisms.
Does renal denervation improve blood-pressure response to hemorrhagic shock in spontaneously hypertensive rats?
Renal denervation improves the early blood-pressure response to severe hemorrhagic shock in spontaneously hypertensive rats, potentially via up-regulation of β1-AR.
Cai et al. (2018) studied this question.
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