Viral glycoproteins and H-2 antigens must be co-localized in the same lipid bilayer to effectively elicit and target anti-Sendai virus cytotoxic T lymphocytes.
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Hypothesis-generating for membrane co-localization in antiviral CTL responses; does not support clinical translation without further evidence.
We have investigated the minimal molecular requirements for elicitation of anti-Sendai virus cytotoxic T lymphocytes (CTL), and the minimal molecular requirements for the recognition and lysis processes associated with anti-Sendai virus CTL-target cell interactions. This report demonstrates a) that the hemagglutinin-neuraminidase and/or fusion glycoproteins of Sendai virus can elicit anti-Sendai virus CTL and b) that these glycoproteins and H-2 antigens must be within the same membrane lipid bilayer for effective elicitation of anti-Sendai-virus CTL and for effective recognition and lysis of target cells by anti-Sendai virus CTL.
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Hale et al. (1980) studied this question.
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