Why the study?
Does renal intramedullary infusion of PRO20 reduce mean arterial pressure in a rat model of angiotensin II-induced hypertension?
Does renal intramedullary infusion of PRO20 reduce mean arterial pressure in a rat model of angiotensin II-induced hypertension?
Inhibition of the renal medullary (pro)renin receptor with PRO20 attenuates angiotensin II-induced hypertension and kidney injury in rats.
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Supports preclinical testing of medullary (pro)renin receptor inhibition; leaves open translation to human hypertension.
Wang et al. (2015) studied this question.