May 5, 2010Endocrinology

Regulation of (Pro)Renin Receptor Expression by Glucose-Induced Mitogen-Activated Protein Kinase, Nuclear Factor-κB, and Activator Protein-1 Signaling Pathways

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Population

Rat mesangial cells

Design

Preclinical

Authors

JHJiqian HuangWenzhou Medical University HSHelmy M. SiragyGeneral / Preventive / Lipids

Discussion

Member takes

Implication

May guide future diabetic nephropathy targets; leaves open translation from rat mesangial cells to clinical outcomes.

Structured PICO

Population

Rat mesangial cells

Intervention

Exposure to 30 mm d-glucose and various kinase/transcription factor inhibitors (Chelerythrine, Rottlerin, GW5074, U0126, SP600125, Quinazoline, Curcumin)

Outcome

PRR mRNA and protein expression, and intracellular phosphorylation of Raf-1, ERK, JNK, NF-kappaB p65, and c-Junsurrogate

This preclinical study elucidates the molecular signaling pathways (PKC-Raf-ERK and PKC-JNK-c-Jun) by which high glucose up-regulates the (pro)renin receptor in rat mesangial cells, providing insight into diabetic nephropathy mechanisms.

Cite This Study

Huang et al. (2010) studied this question.

synapsesocial.com/papers/6a8569f0beaf5c5b09108f67 https://doi.org/10.1210/en.2009-1368

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Regulation of (Pro)Renin Receptor Expression by Glucose-Induced Mitogen-Activated Protein Kinase, Nuclear Factor-κB, and Activator Protein-1 Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of (Pro)Renin Receptor Expression by Glucose-Induced Mitogen-Activated Protein Kinase, Nuclear Factor-κB, and Activator Protein-1 Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider