Why the study?
The role of soluble PRR as an essential mediator of aldosterone-salt-induced hypertension and a potential therapeutic target was investigated.
Soluble (pro)renin receptor is an essential mediator of aldosterone-salt-induced hypertension and represents a potential therapeutic target for patients with mineralocorticoid excess.
Caution against targeting soluble PRR clinically; leaves open its role in human mineralocorticoid hypertension pending validation.
We used a novel mouse model with mutagenesis of the cleavage site of PRR to support soluble PRR as an essential mediator of aldosterone-salt-induced hypertension and also as a potential therapeutic target for patients with mineralocorticoid excess. We firstly report that soluble PRR-dependent pathway medicates the Na + -retaining action of aldosterone in the distal nephron, which opens up a new area for a better understanding of the molecular basis of renal handling of Na + balance and blood pressure.
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Fu et al. (2022) studied this question.
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