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January 1, 2011International Journal of Clinical MedicineOpen Access

Angiotensinogen Expression Is Enhanced in the Progression of Glomerular Disease

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Population

Glomerular disease models including anti-glomerular basement membrane nephritis rat model, Zucker diabetic…

Design

Review

Authors

MUMaki UrushiharaTokushima UniversityHKHiroyuki KoboriGeneral / Preventive / Lipids

Discussion

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Overview

Should not yet change glomerular disease management; hypothesis-generating and requires prospective validation.

Structured PICO

P
Population
Glomerular disease models including anti-glomerular basement membrane nephritis rat model, Zucker diabetic fatty (ZDF) obese rats, and primary rat mesangial cells
O
Outcome
Angiotensinogen (AGT) expression in diseased glomerulisurrogate

Enhanced angiotensinogen expression in glomeruli contributes to intrarenal RAS activation and the progression of glomerular disease.

Cite This Study

Urushihara et al. (2011) studied this question.

synapsesocial.com/papers/6a856a676e0f1d231d20287chttps://doi.org/10.4236/ijcm.2011.24064
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Also Consider

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  5. 5Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice2007 · 106 citations