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October 1, 1998Lupus

Association of an insertion polymorphism of angiotensinconverting enzyme gene with the activity of systemic lupus erythematosus

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Why the study?

Is the insertion/deletion polymorphism of the ACE gene associated with disease activity in patients with newly diagnosed SLE?

Population

93 patients with newly diagnosed systemic lupus erythematosus (SLE)

Comparison

ACE gene insertion polymorphism vs ACE gene deletion (D) polymorphism (DD genotype)

Design

Cross-sectional

Authors

HSHiroshi SatoGeneral / Preventive / LipidsYAYasuhiro AkaiNara Medical UniversityMIMasayuki IwanoUniversity of Fukui

Discussion

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Implication

ACE II genotype linked to higher SLE activity; hypothesis-generating and requires prospective validation before any clinical use.

Structured PICO

Is the insertion/deletion polymorphism of the ACE gene associated with disease activity in patients with newly diagnosed SLE?

P
Population
93 patients with newly diagnosed systemic lupus erythematosus (SLE)
I
Intervention
ACE gene insertion (I) polymorphism (II or DI genotype)
C
Comparator
ACE gene deletion (D) polymorphism (DD genotype)
O
Outcome
Disease activity of SLE measured by serum levels of anti-dsDNA antibody, total complements (CH50), and SLEDAI scoresurrogate

The ACE gene insertion polymorphism (II genotype) is associated with increased disease activity in patients with newly diagnosed systemic lupus erythematosus.

Cite This Study

Sato et al. (1998) studied this question.

synapsesocial.com/papers/6a856b2f6f8d490ba41e5a35https://doi.org/10.1191/096120398678920622
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes1993 · 516 citations
  2. 2The 1982 revised criteria for the classification of systemic lupus erythematosus1982 · 14,652 citations
  3. 3An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.1990 · 3,817 citations
  4. 4Bradykinin stimulates tumor necrosis factor and interleukin‐1 release from macrophages1989 · 242 citations