Key result
The ACE D allele and DD genotype were significantly associated with increased susceptibility to systemic lupus erythematosus (OR 1.29 and 1.60, respectively), and the DD genotype was associated with lupus nephritis risk (OR 2.78).
Why the study?
Does the ACE I/D gene polymorphism predict the risk of systemic lupus erythematosus and lupus nephritis?
Meta-Analysis (n=4,037)
Does the ACE I/D gene polymorphism predict the risk of systemic lupus erythematosus and lupus nephritis?
Odds Ratio: 1.29 (95% CI 1.04–1.58)
p-value: p=0.02
The ACE D allele and DD genotype are significant genetic markers associated with increased susceptibility to systemic lupus erythematosus and lupus nephritis.
OBJECTIVE: Results from studies of the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and systemic lupus erythematosus (SLE)/lupus nephritis (LN) are controversial. We performed this metaanalysis to evaluate the relationship between ACE I/D gene polymorphism and SLE/LN and to explore whether the ACE D allele or DD genotype could become a predictive marker for risk of SLE/LN. METHODS: Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of May 1, 2011, and eligible investigations were synthesized using a metaanalysis method. Results were expressed with OR for dichotomous data, and 95% CI were calculated. RESULTS: Sixteen investigations were identified for the analysis of association between ACE I/D gene polymorphism and SLE, consisting of 1959 patients with SLE and 2078 controls. In the overall populations, there was a marked association between D allele or DD genotype and SLE susceptibility (D: OR 1.29, 95% CI 1.04-1.58, p = 0.02; DD: OR 1.60, 95% CI 1.17-2.19, p = 0.003), and DD homozygous was associated with LN risk (OR 2.78, 95% CI 1.26-6.11, p = 0.01). In the subgroup analysis, DD genotype associated with SLE risk was observed in Asians; no other association was found in Asians, whites, Africans, and Brazilians. CONCLUSION: D allele and DD homozygous are significant genetic molecular markers to predict SLE susceptibility, and DD genotype is a valuable marker to predict the LN risk. More investigations are required to clarify the association of the D allele or DD homozygous with SLE/LN susceptibility.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2012) conducted a meta-analysis in Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) (n=4,037). ACE D allele or DD genotype vs. ACE I allele or II/ID genotypes was evaluated on Systemic lupus erythematosus (SLE) susceptibility for D allele vs I allele (OR 1.29, 95% CI 1.04-1.58, p=0.02). The ACE D allele and DD genotype were significantly associated with increased susceptibility to systemic lupus erythematosus (OR 1.29 and 1.60, respectively), and the DD genotype was associated with lupus nephritis risk (OR 2.78).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: