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December 1, 1997Hypertension

Mannose 6-Phosphate Receptor–Mediated Internalization and Activation of Prorenin by Cardiac Cells

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Population

Neonatal rat cardiac myocytes and fibroblasts cultured in a chemically defined medium

Design

Preclinical

Authors

CKCatharina A. M. van KesterenErasmus University RotterdamADA.H. Jan DanserVascular MedicineFDF. H. M. DerkxGeneral / Preventive / Lipids

Discussion

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Implication

Hypothesis-generating for local cardiac angiotensin production in animals; should not yet inform clinical hypertension management.

Structured PICO

P
Population
Neonatal rat cardiac myocytes and fibroblasts cultured in a chemically defined medium
I
Intervention
Recombinant human renin and prorenin (2500 microU/mL)
O
Outcome
Binding, internalization, and activation of proreninsurrogate

Demonstrates that prorenin is internalized and activated in cardiac cells via a mannose 6-phosphate receptor-dependent process, suggesting a mechanism for local cardiac angiotensin production.

Cite This Study

Kesteren et al. (1997) studied this question.

synapsesocial.com/papers/6a856b658104700891671d45https://doi.org/10.1161/01.hyp.30.6.1389
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular renin-like activity and blood pressure maintenance in the rat. Studies of the effect of changes in sodium balance, hypertension and nephrectomy.1979 · 105 citations
  2. 2Angiotensin formation in the isolated rat hindlimb1989 · 68 citations
  3. 3Angiotensin II Type 1 (AT1) Receptor–Mediated Accumulation of Angiotensin II in Tissues and Its Intracellular Half-life In Vivo1997 · 189 citations
  4. 4The influence of glycosylation on the fate of renin expressed in Xenopus oocytes1990 · 10 citations
  5. 5Assessment of the role of the renin‐angiotensin system in cardiac contractility utilizing the renin inhibitor remikiren1996 · 17 citations