September 1, 1995Journal of Cerebral Blood Flow & Metabolism

The Role of Neuronal Nitric Oxide Synthase in Regulation of Cerebral Blood Flow in Normocapnia and Hypercapnia in Rats

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Why the study?

Does 7-nitroindazole reduce cerebral blood flow in fentanyl/N2O-anesthetized rats?

Population

fentanyl/N2O-anesthetized rats

Design

Preclinical

Authors

QWQiong WangFirst People’s Hospital of Jingmen DPDale A. PelligrinoBrigham and Women's Hospital VBVerna L. BaughmanUniversity of Illinois Chicago

Discussion

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Implication

7-NI effects in rats support nNOS regulation of CBF; leaves open translation to human cerebrovascular physiology.

Structured PICO

Does 7-nitroindazole reduce cerebral blood flow in fentanyl/N2O-anesthetized rats?

Population

fentanyl/N2O-anesthetized rats

Intervention

7-nitroindazole (7-NI) 80 mg kg-1 i.p.

Outcome

Cerebral blood flow (CBF) during normocapnia and hypercapnia measured using laser-Doppler flowmetrysurrogate

Inhibition of neuronal nitric oxide synthase with 7-nitroindazole reduces resting cerebral blood flow and the hypercapnic response in rats, indicating nNOS-derived NO regulates basal and hypercapnia-induced cerebral blood flow.

Cite This Study

Wang et al. (1995) studied this question.

synapsesocial.com/papers/6a856ec035bc0eada8d59d4b https://doi.org/10.1038/jcbfm.1995.97

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The Role of Neuronal Nitric Oxide Synthase in Regulation of Cerebral Blood Flow in Normocapnia and Hypercapnia in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Role of Neuronal Nitric Oxide Synthase in Regulation of Cerebral Blood Flow in Normocapnia and Hypercapnia in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider