Why the study?
Does nitric oxide synthase inhibition depress the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension in rats?
Population
42 anesthetized (halothane and N2O) male Sprague-Dawley rats prepared with a superfused closed cranial window
Comparison
Nitric oxide synthase inhibition via superfusion vs Time control, enantiomer control, and reinfusion…
Design
Preclinical
Authors
Loading...
NOS inhibition may impair CBF autoregulation during hypotension in rats; hypothesis-generating, leaves open human relevance.
Does nitric oxide synthase inhibition depress the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension in rats?
Nitric oxide synthase inhibition depresses the autoregulatory pattern and decreases the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension, suggesting nitric oxide augments the hypotensive portion of the curve.
Jones et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: