Why the study?
Does nitric oxide modulation affect dynamic autoregulation of renal blood flow in conscious dogs?
Population
Conscious resting dogs (n=7 for L-NAME, n=5 for L-NAME + SNAP)
Comparison
NO synthase inhibition with NG-nitro-L-arginine… vs Control conditions
Design
Preclinical
Follow-up
2 hours per condition
Authors
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NO supports frequency-specific renal autoregulation in dogs; hypothesis-generating for human CKD or hypertension studies.
Does nitric oxide modulation affect dynamic autoregulation of renal blood flow in conscious dogs?
Nitric oxide contributes to renal blood flow autoregulation through phasic modulation and helps prevent resonance of the myogenic response.
Just et al. (1999) studied this question.
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