Why the study?
Does nitric oxide synthase inhibition alter the autoregulation of renal blood flow and glomerular filtration rate in aging spontaneously hypertensive rats?
Population
Aging spontaneously hypertensive rats, young SHR, and age-matched Wistar-Kyoto rats
Comparison
Infusion of NOS inhibitor N-monometyl-L-arginine… vs Baseline before infusion or Ringer solution
Design
Preclinical
Authors
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NO dependence of GFR autoregulation in aged SHR supports mechanistic studies; leaves open relevance to human hypertension or CKD.
Does nitric oxide synthase inhibition alter the autoregulation of renal blood flow and glomerular filtration rate in aging spontaneously hypertensive rats?
In aging hypertensive rats, glomerular filtration rate autoregulation is strongly dependent on nitric oxide, suggesting postglomerular contraction during NOS inhibition.
Kvam et al. (2000) studied this question.
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