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November 18, 2003The Journal of Pathology

Expression of interleukin‐6 and monocyte chemoattractant protein‐1 by peritoneal sub‐mesothelial cells during abdominal operations

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Population

Patients undergoing major abdominal operations

Comparison

Major abdominal operation (surgical trauma) vs Baseline

Design

Other

Follow-up

5 hours (ex vivo incubation)

Authors

JRJanik RieseGNGerald NiedobitekRLRenate Lisner

Discussion

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Overview

Does not support practice changes; hypothesis-generating for peritoneal cytokine modulation in abdominal surgery.

Structured PICO

P
Population
Patients undergoing major abdominal operations (peritoneal tissue samples taken at the beginning and end of operations)
I
Intervention
Major abdominal operation (surgical trauma)
C
Comparator
Baseline (tissue samples taken at the start of the operation)
O
Outcome
Concentrations of IL-6 and MCP-1 in culture supernatants and identification of cells expressing IL-6 or MCP-1surrogate

Peritoneal endothelial and smooth muscle cells are major contributors to the transient increase in IL-6 and MCP-1 following surgical trauma during abdominal operations.

Cite This Study

Riese et al. (2003) studied this question.

synapsesocial.com/papers/6a856fdfb61bc202bc1e596chttps://doi.org/10.1002/path.1455
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PRODUCTION OF IL-6 AND MCP-1 BY THE HUMAN PERITONEUM IN VIVO DURING MAJOR ABDOMINAL SURGERY2000 · 33 citations
  2. 2Chemokines produced by mesothelial cells: huGRO-α, IP-10, MCP-1 and RANTES1998 · 91 citations
  3. 3Catecholamines up‐regulate lipopolysaccharide‐induced IL‐6 production in human microvascular endothelial cells2000 · 76 citations
  4. 4Induction of Monocyte Chemoattractant Protein-1 Synthesis in Human Monocytes During Transendothelial Migration In Vitro1995 · 106 citations