Troponin, B‐type natriuretic peptides and outcomes in severe heart failure: Differences between ischemic and dilated cardiomyopathies
Key result
In patients with acute heart failure, ischemic cardiomyopathy was associated with higher troponin and BNP levels and greater cardiovascular mortality (48% vs 23%, p<0.05) compared to idiopathic dilated cardiomyopathy.
Why the study?
Do biomarker levels of troponin and natriuretic peptides differ between ischemic and idiopathic dilated etiologies of severe heart failure?
Population
40 patients admitted to hospital for acute heart failure, with either ischemic or idiopathic dilated…
Design
Cohort
Follow-up
10 +/- 1 months
Authors
Discussion
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Member takes
Implication
May inform etiology-specific risk stratification in acute HF; leaves open whether ischemic cardiomyopathy warrants distinct management.
Study Design
Type
Cohort (n=40)
Structured PICO
Do biomarker levels of troponin and natriuretic peptides differ between ischemic and idiopathic dilated etiologies of severe heart failure?
P
Population
40 patients (mean age 68, 32.5% female) admitted for acute heart failure with severe systolic dysfunction (LVEF ~25%), followed for approximately 10 months.
O
Outcome
Biomarker levels of troponin T, troponin I, B-type natriuretic peptide (BNP), and N-terminal prohormone brain natriuretic peptide (NT-proBNP) at admissionsurrogate
Main Result
Absolute Event Rate: 48% vs 23%
p-value: p=<0.05
Patients with acutely decompensated heart failure due to ischemic cardiomyopathy have significantly higher levels of troponin and BNP, and higher mortality, compared to those with idiopathic dilated cardiomyopathy.
Cite This Study
Miller et al. (2007) conducted a cohort in Acute heart failure (n=40). Ischemic cardiomyopathy vs. Idiopathic dilated cardiomyopathy was evaluated on Cardiovascular mortality (p=<0.05). In patients with acute heart failure, ischemic cardiomyopathy was associated with higher troponin and BNP levels and greater cardiovascular mortality (48% vs 23%, p<0.05) compared to idiopathic dilated cardiomyopathy.