Population
Cultured rat kidney cells
Design
Preclinical
Authors
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Provides mechanistic insight into sCT desensitization in rat kidney cells; leaves open translation to human physiology or therapy.
In cultured rat kidney cells, salmon calcitonin causes persistent adenylate cyclase activation via tight receptor binding, while desensitization is driven by a reduction in available receptor sites.
Chao et al. (1983) studied this question.
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