Key result
Salmon calcitonin activates both adenylyl cyclase and phospholipase C via cloned porcine calcitonin receptors.
Population
MC-3T3 cells stably transfected with cloned porcine kidney calcitonin receptor (PC-1 cells) and LLC-PK1 cells
Design
Preclinical
Authors
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Hypothesis-generating for calcitonin receptor signaling; leaves open translation to human renal physiology or therapy.
The cloned porcine calcitonin receptor functionally couples to both adenylyl cyclase and phospholipase C, similar to the parathyroid hormone receptor.
Force et al. (1992) studied this question. Salmon calcitonin (SCT) vs. Calcitonin gene-related peptide (CGRP) was evaluated on cAMP accumulation and cytosolic free Ca2+ concentration. The cloned porcine calcitonin receptor functionally couples to and activates both adenylyl cyclase and phospholipase C in response to salmon calcitonin.
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