A Study of Correlation between Proteinuria and Histological Findings in Lupus Nephritis Patient

This is the authors' abstract. We don't add key points for this paper.

Systemic Lupus Erythematosus (SLE) is a multisystem auto-immune disease with wide spectrum of clinical and immunological abnormalities including development of auto-antibodies against DNA and other nuclear antigen. All organ tissues may be involved but the skin, joints, heart, nervous system and kidneys are most commonly affected. Clinical evidence of renal disease occurs in 40 to 75% of patients with SLE. The persistent proteinuria is the most frequent sign of the LN (Lupus Nephritis) and occurs in 70% of patients. A study was done involved 30 patients of Lupus Nephritis hospitalized in the Nephrology department of Chittagong Medical College Hospital, Chittagong, Bangladesh, between May 2010 to April 2011 to find correlation between proteinuria and the histological type of Lupus Nephritis. Dependent variable like proteinuria and independent variables like different histological types were analyzed by chi 2 , ANOVA and Pearson's correlations test. All patients was found female. Average age of patient was 27.17+ _ 9.51 years. Positive ANA titre was found in 77% of patient and positive Anti Ds DNA titre in 100% of patients. Common histological type was found class IV. We had found a positive correlation between the values of proteinuria with histological classes of Lupus Nephritis.