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January 1, 2003Thrombosis and Haemostasis

Regulation of protease-activated receptor 1 (PAR1) on platelets and responsiveness to thrombin receptor activating peptide (TRAP) during systemic inflammation in humans

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Key result

This document is a journal masthead and does not contain clinical study data.

Why the study?

Does endotoxin-induced systemic inflammation alter PAR1 expression and platelet responsiveness to TRAP in healthy men?

Population

40 healthy men

Design

Cohort

Follow-up

6 hours

Authors

RRRosemarie ReiterUniversity of ViennaUDUlla DerhaschnigMedical University of ViennaASAlexander SpielMedical University of Vienna

Discussion

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Implication

Journal masthead yields no data; leaves open whether endotoxin alters platelet PAR1 expression or responsiveness.

Structured PICO

Does endotoxin-induced systemic inflammation alter PAR1 expression and platelet responsiveness to TRAP in healthy men?

P
Population
40 healthy men
I
Intervention
Endotoxin (2 ng/kg) infusion
O
Outcome
In vivo regulation of PAR1 and associated responsiveness of human platelets to thrombin receptor activating peptide (TRAP)surrogate

Systemic inflammation induced by endotoxin down-regulates PAR1 expression on platelets, leading to decreased responsiveness to subsequent PAR1 stimulation.

Cite This Study

Reiter et al. (2003) studied this question. This document is a journal masthead and does not contain clinical study data.

synapsesocial.com/papers/6a8579a9ee60e6e86dae60a2https://doi.org/10.1160/th03-04-0245
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Also Consider

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  2. 2Activation of calcium-dependent calmodulin by calcium(II)3(3,5-diisopropylsalicylate)6(H2O)6 decreases thrombin receptor activating peptide-induced P-selectin expression2003 · 2 citations
  3. 3Effects of Endotoxemia on Thrombopoiesis in Men1999 · 93 citations
  4. 4Differences in Platelet α-granule Release between Normals and Immune Thrombocytopenic Patients and between Young and Old Platelets1998 · 38 citations