Key result
Thrombin and TRAP exhibited potent barrier protective and cytoprotective effects in human pulmonary artery endothelial cells when EPCR was occupied by PC-S195A.
Population
Human pulmonary artery endothelial cells (HPAECs)
Comparison
Thrombin and thrombin receptor agonist peptide… vs Thrombin or TRAP without prior PC-S195A treatment
Design
Preclinical
Authors
Loading...
Protective thrombin effects via EPCR-PAR-1 in pulmonary endothelium are hypothesis-generating; leaves open therapeutic targeting in vascular injury.
Occupancy of EPCR by its natural ligand recruits PAR-1 to a protective signaling pathway in pulmonary artery endothelial cells, switching thrombin's effect from disruptive to protective.
Bae et al. (2008) studied this question. Thrombin and TRAP with PC-S195A pretreatment vs. Without PC-S195A pretreatment was evaluated on Permeability barrier and cytoprotective activity. Thrombin and TRAP exhibited potent barrier protective and cytoprotective effects in human pulmonary artery endothelial cells when EPCR was occupied by PC-S195A.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: