Population
Endothelial cells (in vitro model)
Comparison
Protein C activation by anticoagulant double… vs Exogenous activated protein C and protein C…
Design
Preclinical
Authors
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Should not yet inform clinical practice; hypothesis-generating for thrombin WE in systemic inflammation.
Endogenous protein C activation on the endothelial cell surface is mechanistically linked to highly efficient PAR1-dependent barrier protective signaling, suggesting therapeutic potential for thrombin WE in systemic inflammation.
Feistritzer et al. (2006) studied this question.
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