Why the study?
Does targeted deletion of the AT1A receptor protect mice from progressive nephropathy induced by overload proteinuria?
Population
Uninephrectomized genetically modified mice lacking the major isoform of murine AT1 receptor and wild-type…
Comparison
Daily injection of bovine serum albumin to… vs Daily injection of saline
Design
Preclinical
Follow-up
4 or 11 weeks
Authors
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AT1A deletion does not prevent proteinuric injury in mice; leaves open Ang II-independent mechanisms as targets in human CKD models.
Does targeted deletion of the AT1A receptor protect mice from progressive nephropathy induced by overload proteinuria?
Targeted deletion of the AT1A receptor does not prevent disease progression in a mouse model of overload proteinuria, suggesting that the toxic effect of protein trafficking is not necessarily dependent on Ang II.
Benigni et al. (2004) studied this question.
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