Why the study?
Does overexpression of angiotensin type 2 receptor ameliorate glomerular injury in a mouse remnant kidney model?
Population
AT2R transgenic mice overexpressing AT2R under the control of alpha-smooth muscle actin promoter, and…
Comparison
Overexpression of angiotensin type 2 receptor vs Wild-type mice subjected to (5/6) nephrectomy
Design
Preclinical
Follow-up
12 weeks
Authors
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May attenuate glomerular injury in experimental CKD models; leaves open translation to human therapy.
Does overexpression of angiotensin type 2 receptor ameliorate glomerular injury in a mouse remnant kidney model?
Overexpression of the angiotensin type 2 receptor protects against glomerular injury in a mouse model of 5/6 nephrectomy, highlighting a potential therapeutic target for glomerular disorders.
Hashimoto et al. (2004) studied this question.
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