What question did this study set out to answer?

Develop and validate a sensitive and specific radioimmunoassay system to measure human follicle-stimulating hormone concentrations in biological samples.

February 1, 1967The Journal of Clinical Endocrinology & Metabolism

Radioimmunoassay for Human Follicle-Stimulating Hormone1

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AMA. REES MIDGLEYMichigan Medicine

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Implication

Laboratory assay development demonstrates specific radioimmunoassay quantification of human follicle-stimulating hormone, highlighting improved diagnostic monitoring of reproductive endocrine...

Key Points

Develop and validate a sensitive and specific radioimmunoassay system to measure human follicle-stimulating hormone concentrations in biological samples.
Generated antibodies against human follicle-stimulating hormone to establish a competitive radioimmunoassay system.
Employed radioiodinated hormone tracers to measure displacement curves against purified reference hormone preparations.
Assessed immunological cross-reactivity against related pituitary glycoprotein hormones to evaluate specificity.
Established a functional radioimmunoassay capable of detecting low physiological concentrations of human follicle-stimulating hormone.
Achieved distinct immunological discrimination of follicle-stimulating hormone with minimal cross-reactivity from related gonadotropins.

Cite This Study

A. REES MIDGLEY (1967) studied this question.

synapsesocial.com/papers/6a8581ed11328e0a2aae5e83 https://doi.org/10.1210/jcem-27-2-295

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Implication

Laboratory assay development demonstrates specific radioimmunoassay quantification of human follicle-stimulating hormone, highlighting improved diagnostic monitoring of reproductive endocrine...

Radioimmunoassay for Human Follicle-Stimulating Hormone1

Discussion

Member takes

Implication

Key Points

Cite This Study

Radioimmunoassay for Human Follicle-Stimulating Hormone1

Discussion

Member takes

Implication

Key Points

Cite This Study

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