Key result
Early twentieth-century investigations into muscle energetics by Meyerhof and Hill led to the discovery of ATP as the direct fuel for muscle contraction.
This historical review highlights the foundational early 20th-century discoveries that established ATP as the direct fuel for muscle contraction.
Educates on ATP's discovery in muscle; leaves open integration into contemporary cardiac bioenergetics research.
The dawn of muscle energetics began in the early twentieth century when Otto Meyerhof and A. V. Hill made bold attempts to link biochemical studies with thermal measurements during muscle contraction. In the search for the direct fuel for muscle contraction, lactic acid formation and phosphocreatine breakdown turned out to be false trails. Nonetheless, these investigations led to the discovery of ATP and the proposal of ATP as the direct fuel for muscle contraction.
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Jack A. Rall (2023) conducted a review in Muscle contraction. Early twentieth-century investigations into muscle energetics by Meyerhof and Hill led to the discovery of ATP as the direct fuel for muscle contraction.
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