Key result
Historical thermodynamics prompt reconsidering the link between water energetics and ATP hydrolysis in molecular motors.
Why the study?
The link between the energetics of water and ATP hydrolysis energy in molecular motors requires reconsideration based on historical and thermodynamic insights.
This paper proposes a reconsideration of the thermodynamic link between water energetics and ATP hydrolysis in molecular motors.
May extend thermodynamic models to molecular muscle studies; leaves open clinical translation in cardiology.
Mechanical energy from oxygen metabolism by mammalian tissues has been studied since 1837. The production of heat by mechanical work was studied by Fick in about 1860. Prior to Fick's work, energetics were revised by Joule's experiments which founded the First Law of Thermodynamics. Fenn in 1923/24 found that frog muscle contractions generated extra heat proportional to the amount of work done in shortening the muscle. This was fully consistent with the Joule, Helmholtz concept used for the First Law of Thermodynamics. The link between the energetics of water and ATP hydrolysis in molecular motors is recommended for reconsideration.
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W. F. Widdas (2008) conducted a review in Energetics of water and ATP hydrolysis in molecular motors. A reconsideration of the link between the energetics of water and ATP hydrolysis in molecular motors is recommended based on historical thermodynamic principles.
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