What question did this study set out to answer?

To review evidence detailing how perioperative medications influence immune responses, cytokine balance, and leukocyte function.

May 1, 1996AnaesthesiaOpen Access

Immunomodulation: an important concept in modern anaesthesia

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Authors

WMWilliam T. McBrideBelfast Health and Social Care Trust MAMervyn ArmstrongSiemens (Netherlands)SMS.J. McBrideGreenwich Hospital

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Implication

Narrative review demonstrates perioperative drug effects on immune function in surgical patients, indicating that anesthetic choices modulate cytokine balance and cell-mediated immunity.

Key Points

To review evidence detailing how perioperative medications influence immune responses, cytokine balance, and leukocyte function.
Narrative synthesis of in vitro and clinical evidence examining perioperative immunomodulation.
Evaluation of the biological effects of non-steroidal anti-inflammatory agents, phosphodiesterase inhibitors, opioids, and general anesthetics on cytokine dynamics and cellular immunity.
Non-steroidal anti-inflammatory drugs, phosphodiesterase inhibitors, and opioids alter the balance of pro- and anti-inflammatory cytokines via intracellular cyclic nucleotide signaling pathways.
Neutrophil activity is suppressed by intravenous induction agents but enhanced by opioids, while natural killer cell function is transiently depressed by volatile anesthetics and opioids but stimulated by catecholamines.
Perioperative reductions in circulating immunoglobulin concentrations occur primarily through hemodilution rather than direct drug-mediated suppression.

Cite This Study

McBride et al. (1996) studied this question.

synapsesocial.com/papers/6a85826a9bde72dc3520197c https://doi.org/10.1111/j.1365-2044.1996.tb07793.x

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Implication

Narrative review demonstrates perioperative drug effects on immune function in surgical patients, indicating that anesthetic choices modulate cytokine balance and cell-mediated immunity.

Immunomodulation: an important concept in modern anaesthesia

Discussion

Member takes

Implication

Key Points

Cite This Study

Immunomodulation: an important concept in modern anaesthesia

Discussion

Member takes

Implication

Key Points

Cite This Study

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