Why the study?
Does percutaneous transluminal renal angioplasty improve blood pressure control in hypertensive patients?
Does percutaneous transluminal renal angioplasty improve blood pressure control in hypertensive patients?
Renal angioplasty is most effective for achieving long-term hypertension cure in patients with fibromuscular disease and lateralizing renal vein renin values.
Hypothesis-generating; renal angioplasty may benefit fibromuscular more than atherosclerotic disease but requires randomized confirmation.
Percutaneous transluminal angioplasty was performed in 31 hypertensive patients with primary success in 26 patients (83%). Twenty-three patients had a mean follow-up of 13 months. The cure rate was 30% with a further 26% being improved. However, in the group of patients with lateralizing renal vein renin values, the cure rate rose to 47% with a further 33% improved. Of the eight patients with fibromuscular disease, 83% were normotensive without medication at follow-up; in the 13 patients with atherosclerotic disease, 22% were cured and 44% were classified as improved. Patients with fibromuscular disease and lateralization of renin production are the best candidates for long-term success.
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Martin et al. (1981) studied this question.
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