Population
Six conscious healthy dogs with chronically maintained femoral arterial catheters.
Comparison
Rapid 15 ml/kg hemorrhage vs Baseline/steady state levels before hemorrhage
Design
Preclinical
Authors
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These canine responses should not alter human hemorrhage management; leaves open ACTH-corticosteroid dissociation mechanisms for targeted study.
In conscious dogs, rapid hemorrhage increases adrenal secretion of corticosteroids, which is underestimated by peripheral plasma levels, with apparent dissociation from ACTH responses.
Wood et al. (1982) studied this question.
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