Renin, ACTH, and adrenocortical function during hypoxia and hemorrhage in conscious rats

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Population

21 conscious male rats with chronic femoral arterial catheters (n=7 per group)

Comparison

Exposure to chronic hypoxia for 42 hours… vs Exposure to normoxia for 42 hours followed by a…

Design

Preclinical

Follow-up

42 hours

Authors

Discussion

Hypoxia-hemorrhage interactions in rats are hypothesis-generating; leaves open human relevance and precludes practice change.

Population

21 conscious male rats with chronic femoral arterial catheters (n=7 per group)

Intervention

Exposure to chronic hypoxia (12.5% or 10% O2) for 42 hours followed by a rapid 6 ml/kg hemorrhage

Comparator

Exposure to normoxia (21% O2) for 42 hours followed by a rapid 6 ml/kg hemorrhage

Outcome

Renin, ACTH, aldosterone, and corticosterone responses to acute hemorrhagesurrogate

Chronic exposure to severe hypoxia augments the pituitary-adrenal but not the renin-aldosterone response to hemorrhage in a rat model.

Raff et al. (1986) studied this question.

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