Why the study?
Does chronic hypobaric hypoxia alter the renin-angiotensin-aldosterone system in Wistar rats?
Does chronic hypobaric hypoxia alter the renin-angiotensin-aldosterone system in Wistar rats?
Chronic severe hypobaric hypoxia in rats induces a dissociation between the renin-angiotensin system and aldosterone, characterized by increased plasma renin activity but unchanged aldosterone levels.
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Hypoxia effects on rat RAAS should not guide clinical decisions; leaves open aldosterone regulation in human hypoxic states.
Plasma renin activity (PRA), plasmatic aldosterone, haematocrit, haemoglobin concentration and plasma proteins were measured in 36 Wistar rats of both sexes submitted to 380 mmHg in hypopressure chamber during 7 months and in a group of control animals (15 male and 15 female rats). PRA was significantly increased in hypoxic male (P less than 0.05) and female (P less than 0.01) rats. On the contrary, plasma aldosterone concentration did not show any significant variation. There thus was a clear dissociation between the plasmatic renin-angiotensin system and the aldosterone in rats of both sexes submitted to severe chronic hypobaric hypoxia.
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Martín et al. (1982) studied this question.
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