Why the study?
Is switching beta-blockers safe and well-tolerated in patients with mild-to-severe chronic heart failure?
Population
1,321 patients with mild-to-severe chronic heart failure (CHF) from the poststudy phase of the COMET trial
Comparison
Transitioning to open-label beta-blockade… vs Switching from carvedilol to metoprolol vs…
Design
Cohort, open-label
Follow-up
30 days
Authors
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Switching carvedilol to metoprolol was associated with higher HF events; leaves open causality versus confounding in observational data.
Is switching beta-blockers safe and well-tolerated in patients with mild-to-severe chronic heart failure?
Switching beta-blockers in heart failure patients is generally safe, but transitioning from carvedilol to metoprolol is associated with higher rates of adverse events and hospitalization compared to switching from metoprolol to carvedilol.
Lenarda et al. (2005) studied this question.
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