Understanding the chemotherapy of tuberculosis—current problems

D A Mitchison

doi:10.1093/jac/29.5.477

January 1, 1992Journal of Antimicrobial Chemotherapy

Understanding the chemotherapy of tuberculosis—current problems

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Key Points

Review the microbiological principles and clinical challenges underlying multi-drug chemotherapy for tuberculosis.
Expert narrative review synthesizing clinical pharmacology and bacteriological evidence on anti-tuberculosis drug actions.
Evaluation of factors driving treatment duration, relapse rates, and bacterial eradication.
Bacterial persistence in semi-dormant metabolic states limits the sterilizing efficiency of standard antimicrobial regimens.
Incomplete bactericidal eradication necessitates prolonged multi-agent treatment protocols to prevent relapse and curb acquired drug resistance.

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Implication

Expert review examines persistent challenges in tuberculosis chemotherapy, highlighting the biological barriers to bacterial clearance and drug resistance.

Abstract

D. A. Mitchison; Understanding the chemotherapy of tuberculosis—current problems, Journal of Antimicrobial Chemotherapy, Volume 29, Issue 5, 1 May 1992, Pages 4

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D A Mitchison (1992) studied this question.

synapsesocial.com/papers/6a8583f36e0f1d231d2030ad https://doi.org/10.1093/jac/29.5.477

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Understanding the chemotherapy of tuberculosis—current problems

Key Points

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Abstract

Discussion

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Understanding the chemotherapy of tuberculosis—current problems

Key Points

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Implication

Abstract

Discussion

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