Why the study?
Does oral captopril administration prior to renal vein renin sampling accurately identify patients for surgical treatment of renin-dependent hypertension while shortening the catheterization period?
Does oral captopril administration prior to renal vein renin sampling accurately identify patients for surgical treatment of renin-dependent hypertension while shortening the catheterization period?
Administering captopril prior to renal vein renin sampling simplifies the procedure by eliminating the need for initial selective sampling without compromising accuracy.
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May shorten catheterization for renin-dependent hypertension evaluation; leaves open whether it accurately identifies surgical candidates.
Captopril was administered prior to renal vein renin sampling in an attempt to select patients amenable to surgical treatment for renin dependent hypertension. Renal venous blood for plasma renin activity was taken only after captopril stimulation. Sampling from the antecubital vein before and after this provocation showed a marked rise in renin, thereby confirming the efficacy of the test. Elimination of the initial selective renal vein sampling shortens the catheterization period without affecting the accuracy and dependability of the procedure.
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Rosenthal et al. (1983) studied this question.
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