On the State of the Catechol Amines of the Adrenal Medullary Granules

Summary. Catechol amine containing granules of the cow adrenal medulla were isolated and resuspended in solutions of varying ionic composition. Analyses of the intragranular fluid indicated that the granule membrane is permeable to sodium, potassium, sucrose, and catechol amines. It was concluded that the catechol amines occur in the granules in an osmotically inactive form, probably in combination with an equivalent amount of adenosine triphosphate.