Why the study?
Does Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 reduce mean arterial blood pressure and plasma renin activity in Na-deficient dogs?
Population
In vitro dog and human plasma renin, anesthetized rats receiving hog renin, and conscious Na-deficient dogs
Design
Preclinical
Follow-up
up to 48 hours
Authors
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Minimal BP effect despite PRA suppression at low doses; leaves open renin-independent pathways in Na-deficient hypertension models.
Does Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 reduce mean arterial blood pressure and plasma renin activity in Na-deficient dogs?
A novel statine-containing renin inhibitor lowers blood pressure but shows a dissociation between circulating renin inhibition and blood pressure reduction in sodium-deficient dogs.
Blaine et al. (1984) studied this question.
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