Key result
Ultrasound elasticity imaging accurately measured localized mechanical changes during in-vitro angioplasty, with ultrasound and pathology circumference measurements highly correlated (R2 = 0.94, p = 0.03).
Why the study?
Does high-resolution ultrasound speckle tracking accurately measure vascular strain and structural changes during in-vitro angioplasty in bovine carotid arteries?
Does high-resolution ultrasound speckle tracking accurately measure vascular strain and structural changes during in-vitro angioplasty in bovine carotid arteries?
Effect estimate: R2 0.94
p-value: p=0.03
High-resolution ultrasound elasticity imaging accurately measures localized mechanical changes and vascular strain during angioplasty in an in-vitro model.
Supports preclinical validation of ultrasound elasticity imaging; leaves open human translation for angioplasty guidance.
BACKGROUND: Ultrasound elasticity imaging provides biomechanical and elastic properties of vascular tissue, with the potential to distinguish between tissue motion and tissue strain. To validate the ability of ultrasound elasticity imaging to predict structurally defined physical changes in tissue, strain measurement patterns during angioplasty in four bovine carotid artery pathology samples were compared to the measured physical characteristics of the tissue specimens. METHODS: Using computational image-processing techniques, the circumferences of each bovine artery specimen were obtained from ultrasound and pathologic data. RESULTS: Ultrasound-strain-based and pathology-based arterial circumference measurements were correlated with an R2 value of 0.94 (p = 0.03). The experimental elasticity imaging results confirmed the onset of deformation of an angioplasty procedure by indicating a consistent inflection point where vessel fibers were fully unfolded and vessel wall strain initiated. CONCLUSION: These results validate the ability of ultrasound elasticity imaging to measure localized mechanical changes in vascular tissue.
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Patel et al. (2010) studied Vascular strain during angioplasty (n=5). Ultrasound elasticity imaging during in-vitro angioplasty vs. Pathology-based arterial circumference measurements was evaluated on Correlation between ultrasound-strain-based and pathology-based arterial circumference measurements (R2 0.94, p=0.03). Ultrasound elasticity imaging accurately measured localized mechanical changes during in-vitro angioplasty, with ultrasound and pathology circumference measurements highly correlated (R2 = 0.94, p = 0.03).
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